Mutational Analysis of Merkel Cell Carcinoma
نویسندگان
چکیده
منابع مشابه
Mutational Analysis of Merkel Cell Carcinoma
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine malignancy that is associated with a poor prognosis. The pathogenesis of MCC is not well understood, and despite a recent plethora of mutational analyses, we have yet to find a set of signature mutations implicated in the majority of cases. Mutations, including TP53, Retinoblastoma and PIK3CA, have been documented in subsets ...
متن کاملThe Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma Running Title: Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Affiliations 1. Michigan Center for Translational Pathology, University of Michigan Medical School 2. Department of Pathology, University of Michigan Medical School 3. Department of Dermatology, University of Michigan Medical School 4. Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, India 5. Department of Urology, Henry Ford Health System, Detroit, MI 6. Howard Hugh...
متن کاملThe Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma.
Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine tumor. Merkel cell polyomavirus (MCPyV) may contribute to tumorigenesis in a subset of tumors via inhibition of tumor suppressors such as retinoblastoma (RB1) by mutated viral T antigens, but the molecular pathogenesis of MCPyV-negative MCC is largely unexplored. Through our MI-ONCOSEQ precision oncology study,...
متن کاملDigital Merkel cell carcinoma.
Merkel cell carcinoma (MCC) is a rare and biologically aggressive neuroendocrine tumour of the skin. Recent analysis of a surveillance, epidemiology and end results program has shown a statistically significant increase of 8% per year in the age-adjusted rates for MCC of the skin over the past 15 years. MCC commonly presents as a painless, rapidly growing, single red or purple cutaneous nodule....
متن کاملMerkel cell carcinoma
BACKGROUND Merkel cell carcinoma (MCC) is an unusual primary neuroendocrine carcinoma of the skin. MCC is a fatal disease, and patients have a poor chance of survival. Moreover, MCC lacks distinguishing clinical features, and thus by the time the diagnosis is made, the tumour usually have metastasized. MCC mainly affects sun-exposed areas of elderly persons. Half of the tumours are located in t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancers
سال: 2014
ISSN: 2072-6694
DOI: 10.3390/cancers6042116